1. shychemist:

dicksilhouette:

mindblowingscience:

Want the Best Medical Care? Swallow This Pill Covered in Tiny Needles.

When it comes to medicine, most people prefer pills to needles. But many drugs aren’t properly absorbed when taken in pill form. Now, researchers may have solved the problem: a digestible pill, covered with tiny needles, that injects drugs directly into your stomach lining.
The novel drug delivery system is the result of a collaboration between researchers at MIT and Massachusetts General Hospital. The concept for the pill is described in the video below, but the gist is as follows: A capsule is coated first with tiny needles, then a pH-sensitive coating. The coating not only makes it possible to swallow the pill, it also dissolves away in the low-pH environment of the stomach. When it does, the needles are exposed. Intestinal contractions carry the pill through the digestive tract while applying pressure to an internal drug reservoir. In this way, the drug is delivered via the needles into the intestinal wall, where it can be absorbed. Such a system could one day replace injections of medications like insulin, which are too big to be absorbed via the stomach, and prone to decomposition by gastrointestinal molecules, to be taken orally:
In the latest issue of the Journal of Pharmaceutical Sciences, researchers led by chemical engineer Carl Schoellhammer document the potential of the new drug delivery system. Using a pig as a model, the team demonstrated that injection into the intestines is an effective method of insulin-delivery. In a second experiment, the team showed that a pill measuring two centimeters long, 1 centimeter across, and coated in five-millimeter stainless-steel needles could pass safely through the digestive tract of a pig. Future versions of the pill could be coated with needles made of degradable polymers and sugars:


This seems great and all but what happens when you poop this needle ball out.

Explained in the article:
Future versions of the pill could be coated with needles made of degradable polymers and sugars. 
Also these would likely be so small that you wouldn’t feel them even if they were steel needles.

    shychemist:

    dicksilhouette:

    mindblowingscience:

    Want the Best Medical Care? Swallow This Pill Covered in Tiny Needles.

    When it comes to medicine, most people prefer pills to needles. But many drugs aren’t properly absorbed when taken in pill form. Now, researchers may have solved the problem: a digestible pill, covered with tiny needles, that injects drugs directly into your stomach lining.

    The novel drug delivery system is the result of a collaboration between researchers at MIT and Massachusetts General Hospital. The concept for the pill is described in the video below, but the gist is as follows: A capsule is coated first with tiny needles, then a pH-sensitive coating. The coating not only makes it possible to swallow the pill, it also dissolves away in the low-pH environment of the stomach. When it does, the needles are exposed. Intestinal contractions carry the pill through the digestive tract while applying pressure to an internal drug reservoir. In this way, the drug is delivered via the needles into the intestinal wall, where it can be absorbed. Such a system could one day replace injections of medications like insulin, which are too big to be absorbed via the stomach, and prone to decomposition by gastrointestinal molecules, to be taken orally:

    In the latest issue of the Journal of Pharmaceutical Sciencesresearchers led by chemical engineer Carl Schoellhammer document the potential of the new drug delivery system. Using a pig as a model, the team demonstrated that injection into the intestines is an effective method of insulin-delivery. In a second experiment, the team showed that a pill measuring two centimeters long, 1 centimeter across, and coated in five-millimeter stainless-steel needles could pass safely through the digestive tract of a pig. Future versions of the pill could be coated with needles made of degradable polymers and sugars:

    This seems great and all but what happens when you poop this needle ball out.

    Explained in the article:

    Future versions of the pill could be coated with needles made of degradable polymers and sugars.

    Also these would likely be so small that you wouldn’t feel them even if they were steel needles.

     
  2. allthecanadianpolitics:

Canadians becoming more ‘progressive’: poll

Canadians are increasingly embracing “progressive” values that stand in sharp contrast to Prime Minister Stephen Harper’s brand of conservatism, a new poll has found.
The EKOS Research poll, to be released Thursday at a conference organized in Ottawa by the Canada 2020 think-tank, reveals a shift in public opinion that could have ramifications for next year’s federal election.
On a range of issues – law enforcement, legalization of marijuana, foreign policy, and the appropriate role and size of government – a majority of Canadians are offside with the government, the survey suggests.
The electorate is becoming rapidly polarized, with a wave of Canadians declaring their political ideology to be “small l liberal,” regardless of which political party they support.
Moreover, the poll finds deep discontent among Canadians in key areas: Middle-class anxiety about the economy; a gloomy prediction about the quality of life for the next generation; a dissatisfaction with the “direction” of the government; and a growing distrust of the political system.
The concern about the health of Canada’s democracy is so deep that 56 per cent support the notion that voting in this country should be mandatory, as it is in Australia and Brazil.
The poll was commissioned by Canada 2020, which promotes “progressive solutions” to Canada’s policy problems.
EKOS president Frank Graves said the new polling data show a significant shift in public opinion.
“Values are pretty glacial things,” said Graves. “They don’t typically shift that much but they seem to be moving as a response to, I think, being governed from the right.”
For years, he said, there were no major differences between the Liberals and Progressive Conservatives. But that changed in 2006 when Harper came to power under a new Conservative banner that included previous members of the Reform party.
Harper won three elections with that new political “style” and policy “emphasis,” said Graves.
“They were OK with it for a while,” he said of Canadians, “but it seems now they are going ‘No, that’s enough.’ ”
On that point, the poll shows where Canadians stand on what could be a ballot box question in the 2015 election.
The Liberals and New Democrats are advocating new programs in a range of areas, although the details haven’t been sketched out. The Conservatives, by contrast, have been touting the importance of lean government and tax cuts.
Ekos found 57 per cent of Canadians say the best option for moving Canada forward is by “increasing the role of government to invest in new areas such as job creation, public infrastructure, and stronger social security.”
Meanwhile, 44 per cent say the best option for moving Canada forward is by “reducing the size of government and providing targeted tax relief in order to allow the private sector to propel growth and jobs.”
Graves said there is a disturbing disquiet in the middle class that could become a crisis if left untended.
“When you have a shrinking, pessimistic middle class that feel they are falling backward, that’s never a good harbinger for the future. If that doesn’t get turned around, we’re in huge trouble, I believe.”
mkennedy@ottawacitizen.com
Twitter.com/Mark_Kennedy_
Poll highlights
47: Percentage of people who consider themselves “small l liberal” now, compared to 24 per cent in 2008. The change comes as far fewer people say they have no ideology. Twenty-seven per cent say they are “small c conservative” now, compared to 28 per cent in 2008.
29: Percentage of people who say police should have more powers to ensure security even if it invades Canadians’ privacy, a drop from 60 per cent in 2008.
57: Percentage of people who say marijuana should be legalized, something that is proposed by Liberal leader Justin Trudeau but firmly opposed by Prime Minister Stephen Harper’s government. Twenty-six per cent support decriminalization so that possession of small amounts of pot carries a fine, something that is being considered by the Conservatives. Only 13 per cent say marijuana should remain illegal.
40: Percentage of people who say international development and aid should be utmost in Canada’s foreign policy, compared to 37 per cent who say it should be diplomacy and 16 per cent who say it should be defence.
64:  Percentage of people who think the economy’s “incentive systems” are broken and hard work is no longer paying off.
57: Percentage who think the next generation in 25 years will be “worse off” in terms of quality of life, compared to 26 per cent who think it will be the same and 13 per cent who think it will be better.
56: Percentage who support compulsory voting in Canada. Thirty-one per cent oppose it, and 11 per cent don’t have an opinion.
– Methodology: The poll of 1,549 adult Canadians was conducted Sept. 21 to Sept. 25, 2014 and has a margin of error of 2.5 per cent, 19 times out of 20.
What is Canada 2020?
The poll was commissioned by Canada 2020, which promotes “progressive solutions” to Canada’s policy problems.
More than 400 people will attend its two-day conference in Ottawa, where speakers will include Liberal leader Justin Trudeau, Ontario Premier Kathleen Wynne, former Quebec Premier Jean Charest and Conservative Employment Minister Jason Kenney.
Canada 2020 co-founder Tim Barber said he hopes the conference will focus debate on the proper role of government.
“As a progressive organization, we care about government. We think that government matters. I think there is a need to re-articulate what that vision looks like. And there’s something between the nanny state and the minimalist state that’s the sweet spot,” he said.
– Mark Kennedy, Ottawa Citizen

    allthecanadianpolitics:

    Canadians becoming more ‘progressive’: poll

    Canadians are increasingly embracing “progressive” values that stand in sharp contrast to Prime Minister Stephen Harper’s brand of conservatism, a new poll has found.

    The EKOS Research poll, to be released Thursday at a conference organized in Ottawa by the Canada 2020 think-tank, reveals a shift in public opinion that could have ramifications for next year’s federal election.

    On a range of issues – law enforcement, legalization of marijuana, foreign policy, and the appropriate role and size of government – a majority of Canadians are offside with the government, the survey suggests.

    The electorate is becoming rapidly polarized, with a wave of Canadians declaring their political ideology to be “small l liberal,” regardless of which political party they support.

    Moreover, the poll finds deep discontent among Canadians in key areas: Middle-class anxiety about the economy; a gloomy prediction about the quality of life for the next generation; a dissatisfaction with the “direction” of the government; and a growing distrust of the political system.

    The concern about the health of Canada’s democracy is so deep that 56 per cent support the notion that voting in this country should be mandatory, as it is in Australia and Brazil.

    The poll was commissioned by Canada 2020, which promotes “progressive solutions” to Canada’s policy problems.

    EKOS president Frank Graves said the new polling data show a significant shift in public opinion.

    “Values are pretty glacial things,” said Graves. “They don’t typically shift that much but they seem to be moving as a response to, I think, being governed from the right.”

    For years, he said, there were no major differences between the Liberals and Progressive Conservatives. But that changed in 2006 when Harper came to power under a new Conservative banner that included previous members of the Reform party.

    Harper won three elections with that new political “style” and policy “emphasis,” said Graves.

    “They were OK with it for a while,” he said of Canadians, “but it seems now they are going ‘No, that’s enough.’ ”

    On that point, the poll shows where Canadians stand on what could be a ballot box question in the 2015 election.

    The Liberals and New Democrats are advocating new programs in a range of areas, although the details haven’t been sketched out. The Conservatives, by contrast, have been touting the importance of lean government and tax cuts.

    Ekos found 57 per cent of Canadians say the best option for moving Canada forward is by “increasing the role of government to invest in new areas such as job creation, public infrastructure, and stronger social security.”

    Meanwhile, 44 per cent say the best option for moving Canada forward is by “reducing the size of government and providing targeted tax relief in order to allow the private sector to propel growth and jobs.”

    Graves said there is a disturbing disquiet in the middle class that could become a crisis if left untended.

    “When you have a shrinking, pessimistic middle class that feel they are falling backward, that’s never a good harbinger for the future. If that doesn’t get turned around, we’re in huge trouble, I believe.”

    mkennedy@ottawacitizen.com

    Twitter.com/Mark_Kennedy_

    Poll highlights

    47: Percentage of people who consider themselves “small l liberal” now, compared to 24 per cent in 2008. The change comes as far fewer people say they have no ideology. Twenty-seven per cent say they are “small c conservative” now, compared to 28 per cent in 2008.

    29: Percentage of people who say police should have more powers to ensure security even if it invades Canadians’ privacy, a drop from 60 per cent in 2008.

    57: Percentage of people who say marijuana should be legalized, something that is proposed by Liberal leader Justin Trudeau but firmly opposed by Prime Minister Stephen Harper’s government. Twenty-six per cent support decriminalization so that possession of small amounts of pot carries a fine, something that is being considered by the Conservatives. Only 13 per cent say marijuana should remain illegal.

    40: Percentage of people who say international development and aid should be utmost in Canada’s foreign policy, compared to 37 per cent who say it should be diplomacy and 16 per cent who say it should be defence.

    64:  Percentage of people who think the economy’s “incentive systems” are broken and hard work is no longer paying off.

    57: Percentage who think the next generation in 25 years will be “worse off” in terms of quality of life, compared to 26 per cent who think it will be the same and 13 per cent who think it will be better.

    56: Percentage who support compulsory voting in Canada. Thirty-one per cent oppose it, and 11 per cent don’t have an opinion.

    – Methodology: The poll of 1,549 adult Canadians was conducted Sept. 21 to Sept. 25, 2014 and has a margin of error of 2.5 per cent, 19 times out of 20.

    What is Canada 2020?

    The poll was commissioned by Canada 2020, which promotes “progressive solutions” to Canada’s policy problems.

    More than 400 people will attend its two-day conference in Ottawa, where speakers will include Liberal leader Justin Trudeau, Ontario Premier Kathleen Wynne, former Quebec Premier Jean Charest and Conservative Employment Minister Jason Kenney.

    Canada 2020 co-founder Tim Barber said he hopes the conference will focus debate on the proper role of government.

    “As a progressive organization, we care about government. We think that government matters. I think there is a need to re-articulate what that vision looks like. And there’s something between the nanny state and the minimalist state that’s the sweet spot,” he said.

    – Mark Kennedy, Ottawa Citizen

    (via politicsartandstuff)

     
  3. iroh:

    socialjusticekoolaid:

    Last Night in Ferguson (9.29-9.30): Protesters gathered yet again, in a truly uplifting night of action and calls for justice. It wasn’t all sunshine and roses, due to the usual antagonism from the police, but it was solidarity at it’s finest. #staywoke #farfromover

    Keep up with the action tonight. Follow the Argus Livestreams and/or BellaAiko from Occupy Oakland.

    nice to see some positive news!

    (via face-down-asgard-up)

     
  4. roachpatrol:

the-real-seebs:

kayinnasaki:

Cyber harassment study reveals the unsurprising!
It still amazes me that I talk to guys who still think they get harassed just as much as women online. Like even from people who aren’t clearly and totally gross dumbasses. It kinda makes me think that, even in the best cases, it might be hard to really understand the sheer difference in frequency. You see a woman get harassed on a game and you go “Oh well I’ve been harassed” without understanding that there is seldom a session for her where that doesn’t happen or understanding what her inbox might look like…

That is a sort of stunning degree of difference.

"The data’s in! Women were lying about online harassment!”
"Aha! We knew it!" 
“Yeah, they’ve been severely underreporting how bad things are for them, turns out.”
"Wait, what?"

    roachpatrol:

    the-real-seebs:

    kayinnasaki:

    Cyber harassment study reveals the unsurprising!

    It still amazes me that I talk to guys who still think they get harassed just as much as women online. Like even from people who aren’t clearly and totally gross dumbasses. It kinda makes me think that, even in the best cases, it might be hard to really understand the sheer difference in frequency. You see a woman get harassed on a game and you go “Oh well I’ve been harassed” without understanding that there is seldom a session for her where that doesn’t happen or understanding what her inbox might look like…

    That is a sort of stunning degree of difference.

    "The data’s in! Women were lying about online harassment!”

    "Aha! We knew it!

    Yeah, they’ve been severely underreporting how bad things are for them, turns out.”

    "Wait, what?"

    (via randomactsofchaos)

     
  5. asylum-art:

Undulatus asperatus: Storm Chaser Captures Mesmerizing Time-Lapse of Clouds Rolling Like Ocean Waves
“Undulatus asperatus” is a cloud formation proposed in 2009 that roughly translates to “roughened or agitated waves.” These dark and stormy clouds travel across the sky in ominous waves, but generally dissipate without an a storm forming.
Storm chaser Alex Schueth was recently in the right place at the right time with his DSLR, and managed to capture one of these formations in the mesmerizing time-lapse video seen above. Watch the video:

via (PetaPixel)

    asylum-art:

    Undulatus asperatus: Storm Chaser Captures Mesmerizing Time-Lapse of Clouds Rolling Like Ocean Waves

    Undulatus asperatus” is a cloud formation proposed in 2009 that roughly translates to “roughened or agitated waves.” These dark and stormy clouds travel across the sky in ominous waves, but generally dissipate without an a storm forming.

    Storm chaser Alex Schueth was recently in the right place at the right time with his DSLR, and managed to capture one of these formations in the mesmerizing time-lapse video seen above.

    Watch the video:


    via (PetaPixel)

    (via shychemist)

     
  6. millennialau:

    Rev Sekou kneeled between protesters and police and prayed, then was thrown into a police vehicle with blood smears all inside of it.

    (via randomactsofchaos)

     
  7. getinvolvedyoulivehere:

    VIDEO: Cops Break into Home Arrest Innocent Woman For Filming Them ~ watch it here: http://bit.ly/1BxvQ74

    (via randomactsofchaos)

     
  8.  
  9. jtotheizzoe:

    Watch A Writhing Aurora in Real Time

    I love me some auroras. They are the visual manifestation of an invisible force field, tongues of light that illuminate Earth’s magnetic shell, which by shielding this blue orb from the onslaught of the charged radiation known as solar wind, makes life itself possible.

    As charged particles belched from the sun strike our planet’s magnetic carapace, they are diverted poleward on electromagnetic conduits and eventually thrust into the upper atmosphere at Earth’s higher latitudes. There, collisions with atmospheric molecules illuminate the sky in green and red atomic excitation spectra. Their downward orientation makes them appear like needles pushing in from space itself, or as if one was gazing upward at a flag flapping vertically in the wind.

    None of that have I ever witnessed with my own eyes, because I live at far too equatorial a latitude for even the largest solar storm to deliver this show to my front door. In learning about auroras through time lapses and astrophotography, which I have done my fair share of here on It’s Okay To Be Smart, I suppose I’ve always assumed they were a slow, gradual thing to behold, moving alomst imperceptibly, but definitely moving, like the way we can watch a cloud dissipate without ever really seeing it happen.

    This video of a recent aurora over Yellowknife, Canada tells a different story. It is moving in real time. Stunning work from photographer Kwon O Chul. Not every aurora moves this fast, but this video completely changes the way I look at auroras.

    I’ve often thought of the auroras as Earth’s own performance art, as if the sun is thanking us nightly for the simple act of noticing. But for this private light show, it is we who should be thanking the sun.

    For more beautiful aurora science check out one of the first videos I ever made for the It’s Okay To Be Smart YouTube channel

    (via shychemist)

     
  10. (Source: antoine-roquentin, via aaron2point0)

     
  11. allthecanadianpolitics:

    Question Period Summary: September 29th, 2014.

    Not really much eventful but parliament was much more civil compared to last week. Tons of questionable statements by the government though. :S

    Tweets by: Always Vote, Tonda MacCharles, Shychemist (me), Luke Savage, Badger Janzen, Ash, George Soule, Dale Smith-Journo

    (via shychemist)

     
  12. thisiswhiteprivilege:

    iwriteaboutfeminism:

    Protesters are angry about these strange negotiations to release protesters. What kind of practice is this?

    September 28th

    The arrest of political dissidents

    (via randomactsofchaos)

     
  13. thepeoplesrecord:

    socialjusticekoolaid:

    Last Night in Ferguson (9.28-9.29): Last night’s protest was one of the in Ferguson this month, proving once again that the residents of Ferguson/STL County are some of the most resilient and inspiring in all the land. The police were literally holding peaceful protesters hostage late into the night (folks who were complying with all police requests) so they could negotiate with the remaining folks to leave, but the protesters didn’t back down. Eventually all arrestees were released, and many plan to be back out there tonight.

    Injustice in Ferguson continues, but despite it, community now thrives too. This is still happening. Are you still paying attention? #staywoke #farfromover

    You cannot jail the resistance!

    (via randomactsofchaos)

     
  14. iwriteaboutfeminism:

    Today, Ferguson is prepared to “keep it moving.”

    September 28th

    (via randomactsofchaos)

     
  15. Mersmerizing Clock Uses 135 Other Clocks To Tell Time | Geekologie

    This is the clock at the Ham Yard Hotel in London. It has 135 smaller clocks synchronized to create mesmerizing geometric patterns in between displaying the time in big block numbers. I could watch it all day. Paint drying and grass growing too. I’m a simple man. “You’re brain dead.” I’M A SIMPLE MAN.